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Liu Ziyi encounters a car accident during her wedding photo shoot and transforms into a "blood-soaked bride" to urgently save a person, escorting the patient back to the hospital. She disagrees with Qin Wenbin on whether to perform immediate craniotomy. Liu Ziyi, based on her professional judgment, decides to perform the craniotomy, over ruling other opinions. Qin Wenbin dresses up to meet his wife returning from abroad, but receives a divorce agreement. After signing the agreement, he learns that his old friend has rented the house to a young doctor. Liu Ziyi's fiancé is sent to her hospital for special reasons, having been sent by his lover after cheating, with an indescribable part of his body stuck in a bottle. Firefighters cut the bottle, and Liu Ziyi is embarrassed and angry. Her fiancé initially denies cheating, but his phone messages reveal the truth, and Liu Ziyi decisively ends the relationship.

Qin Wenbin deals with the patient Gao Nanxing's situation. Nanxing refuses treatment and has a poor relationship with her mother. Nanxing's mother tries to give Qin Wenbin a red envelope, which Liu Ziyi witnesses. Wang Gaosheng fails the professional title exam and is asked by the vice president to organize a marathon race, inviting Qin Wenbin and Liu Ziyi to join. Liu Ziyi mistakenly thinks Wang Gaosheng and Qin Wenbin are talking about her and Guan Yifan. Liu Ziyi's colleagues give her wedding red envelopes, and she doesn't know how to deal with it. Grandma Guan is dissatisfied with Liu Ziyi, believing she doesn't care about her family, and Guan Yifan believes his grandmother.

Liu Ziyi develops a surgical plan for the young patient Xiao Xiao, but the risks are high, and Xiao Xiao's father decides to sign. Liu Ziyi and Qin Wenbin continue to support each other at work, handling various cases. Wang Gaosheng makes progress in organizing the marathon race, and Liu Ziyi and Gu Shiyi decide to join. Guan Yifan's condition stabilizes, and Liu Ziyi considers breaking up with him, but Guan Yifan continues to lie, disappointing Liu Ziyi. Qin Wenbin tries to solve Nanxing's problem, communicating with Nanxing's mother, who has a tough attitude. Gu Shiyi is called back by a patient's family during a date and reluctantly returns to the hospital. Liu Ziyi and Qin Wenbin gradually understand each other at work, and their relationship improves.

Liu Ziyi and Qin Wenbin cooperate well in handling cases, supporting each other. Wang Gaosheng's marathon team gradually takes shape, and everyone starts training. Guan Yifan's condition improves, and Liu Ziyi decides to break up with him. Guan Yifan tries to salvage the relationship, but Liu Ziyi is determined. Qin Wenbin and Pan Yue make progress in their divorce, with Pan Yue asking Qin Wenbin to leave with nothing, which he reluctantly accepts. Nanxing's condition worsens, and Qin Wenbin urgently arranges surgery, with Liu Ziyi participating. The surgery is successful, Nanxing's condition improves, and Qin Wenbin and Liu Ziyi breathe a sigh of relief. Gu Shiyi encounters a difficult patient in the emergency room, and Liu Ziyi comes to help. They successfully save the patient.

Gao Nanxing resists treatment due to pre-operative anxiety. Qin Wenbin discovers that his rebellious behavior stems from a misunderstanding of his mother's remarriage, and successfully resolves his issues. Liu Ziyi is emotionally volatile due to the canceled wedding. Her father learns about it and firmly supports his daughter. He also meets Qin Wenbin at a dessert shop and asks him to help diagnose a neighbor's aunt's heart problem. Zhang Chengpeng's daughter, Zhang Yun, strongly refuses to sign for her father's treatment, while Jiang Yu and Gu Shiyi face the ethical dilemma of a paralyzed elderly patient "seeking death." They gradually get closer while talking in a coffee shop. Jiang Yu joins the marathon club to move into talent housing and unexpectedly becomes Gu Shiyi's neighbor. Gu Shiyi discovers that she has been deceived by her pursuer and breaks up with him.

To thank Wang Gaosheng, Jiang Yu successfully invites fitness enthusiast Gu Shiyi to join the club. Zhang Yun refuses to sign the surgical consent form for her father, Zhang Chengpeng, due to his history of domestic violence. Qin Wenbin's communication fails, while Liu Ziyi, from a female perspective, understands Zhang Yun's past pain and reminds her that she may regret it in the future, and Zhang Yun finally signs. Xiao Xiao's mother invites the ill-fated Pi Pi and his mother to celebrate Xiao Xiao's birthday, and Liu Ziyi specially orders a cake suitable for patients. Nanxing sees Pi Pi coughing while blowing balloons and prepares an air pump to help, then joins Pi Pi at the birthday party. During Zhang Chengpeng's surgery, Qin Wenbin's part has a minor twist but succeeds, and Liu Ziyi's interventional surgery is excellent, making Qin Wenbin admire her medical skills.

Xiao Xiao suddenly has a massive postoperative hemorrhage and is rescued, but falls into brain death, and her parents are devastated. At the same time, Pi Pi's parents, unable to wait for a heart source, make an illegal request to Qin Wenbin to buy a heart on the black market, which is strongly rejected. Qin Wenbin's mother suddenly appears at the hospital and has a conflict with the security guard over the parking of her motorhome. Later, while eating in the cafeteria, Qin Wenbin inadvertently reveals the news of his divorce, and his mother cries in public, causing embarrassment. On the other side, Liu Ziyi is under great psychological pressure during Xiao Xiao's rescue, and breaks down after witnessing the despair of the patient's family.

Liu Ziyi blames herself for the brain death of Xiao Xiao, a patient with a rare disease. Her parents endure their grief and sign an organ donation agreement, giving another child, Pi Pi, a new life. Liu Ziyi is criticized by the hospital for the failed surgery, while Qin Wenbin, who successfully saved Pi Pi, is commended, creating a sharp contrast between the two. Liu Ziyi is pulled into the marathon club while running to vent her emotions, and Qin Wenbin kindly escorts her home, subtly warming their relationship. In the subplot, Jiang Yu's pursuit of Gu Shiyi fails; postoperative patient Zhang Chengpeng makes things difficult for nurse Liu Bei, who endures it because she empathizes with her father's death; and Wang Gaosheng mistakenly believes that the vice president favors Jiang Yu, questions him in person but is refuted, and is embarrassed.

Jiang Yu is angered by his colleague, letting Fang Xingyun move into the talent apartment. Liu Ziyi is complained about for stopping Zhang Chengpeng from harassing nurse Liu Bei, and the director suggests she improve her emotional intelligence. Qin Wenbin and Pan Yue have a conflict over the treatment of their old French friend, Frank. Pan Yue is disappointed with the marriage and proposes a divorce. After a dinner with the five marathon club members, Wang Gaosheng is blamed by his wife, Su Qing, for spending more than 2,000 yuan. The next day, Su Qing misunderstands his relationship with a female patient, and their relationship is tense. Zhang Chengpeng harasses Liu Bei again late at night, and Liu Ziyi sees it and is accused of hitting someone, escalating the incident to the department director.

Liu Ziyi is suspended for testifying for nurse Liu Bei, who was harassed by patient Zhang Chengpeng, but is suspended due to the lack of surveillance footage. She angrily writes "I was wrong" and gives it to the vice president, directly pointing out the hospital's inaction. At the same time, Qin Wenbin tracks down the missing Gao Nanxing, finding him at a campsite through his mother's clues, but their mother-son relationship remains tense after returning to the hospital. Gu Shiyi proposes a "seven-day test" to get rid of her pursuer, Zhang Yu, who arranges to pick her up from work. Liu Ziyi and Gu Shiyi share a "gout meal" late at night, showing the sisterhood under high pressure. Zhang Chengpeng's huge compensation claim, Gao Nanxing's psychological crisis, and Gu Shiyi's emotional entanglement intertwine to create a complex ecosystem of the contemporary medical workplace.

Liu Ziyi, suspended due to Zhang Chengpeng's false accusation, is reinstated after the hospital pays 100,000 yuan in compensation due to collective protests from patients' families against changing surgeons. She voluntarily pays 5,000 yuan to return to her post as soon as possible. Her colleagues Qin Wenbin, Wang Gaosheng, and others secretly support her and organize marathon training to relieve her stress. Under Qin Wenbin's guidance, Gao Nanxing goes from resisting treatment to cooperating with surgery. Xiao Xiao's parents decide to donate their daughter's organs, deepening Liu Ziyi's emotional connection with the patients' families. At the end, the doctors have dinner and mistakenly sit next to the leaders, and their complaints are overheard, leading to an awkward situation that is resolved. The vice president understands the pressure on young doctors and expresses willingness to use 100,000 yuan to uphold the dignity of doctors.

Liu Ziyi is ordered to take over the relapse surgery of philanthropist Huang Tianming, who she operated on years ago, facing dual challenges from hospital pressure and professional ethics. Qin Wenbin successfully rescues Frank, who is transferred to the hospital, demonstrating his professional ability. Gu Shiyi misunderstands Jiang Yu due to repeatedly seeing him with different women, who are actually Jiang Yu's three sisters frequently visiting due to family matters. Gu Shiyi eventually resolves the misunderstanding, and their relationship subtly warms. Wang Gaosheng is mistaken by his wife, Su Qing, for cheating due to helping patient Li Xue get votes, and the chat records trigger a family crisis, forcing him to stay in the hospital duty room. In addition, Pan Yue meets with Qin Wenbin's mother, and although they recognize each other, they know that the marriage is difficult to maintain.

Pan Yue tells Qin Wenbin that she resents him for not trying to save their marriage when she asked for a divorce. They recall their sweet first meeting at the coffee shop, and Qin Wenbin finally changes his wife's contact name back to her real name, ending their marriage completely. On the other side, Wang Gaosheng, with Qin Wenbin's financial assistance, buys a 10,000 yuan handbag to please his wife, Su Qing, successfully resolving the family conflict. Qin Wenbin is thanked by Gao Nanxing's family with a lion dance for successfully saving him, unexpectedly earning the title of "Jianghai Miracle Doctor," but is caught in a scandal due to a Photoshopped incident orchestrated by his mother and Gao Nanxing. Liu Ziyi studies Huang Tianming's condition day and night to persuade him to undergo surgery, discovering that he secretly eats barbecue late at night. Huang Tianming bluntly states that he is giving up treatment and proposes a financial deal, shocking Liu Ziyi.

Liu Ziyi gets a fish bone stuck in her throat while eating, and Qin Wenbin takes her to the hospital for treatment. Liu Ziyi's father takes Aunt Jiang to see a doctor, and she gives her father a box of cherries. Tang Mao, who had previously caused trouble at the hospital, has a relapse, and his brother asks Liu Ziyi to see him by name, but she refuses. The director decides to operate on Tang Mao himself. Tang Mao has a sudden episode during marathon training, and Liu Ziyi eventually operates on him, and the surgery is very successful. Huang Tianming gives up treatment and wants to be discharged, but after Liu Ziyi's persuasion, he still chooses to leave, but Liu Ziyi believes he will come back. Emergency sends in a patient, Xu Ming, who fell from a building. Because his aunt demanded a diagnosis certificate before signing for surgery, the time was delayed, and Xu Ming's rescue ultimately failed.

Xu Ming's death makes Wang Gaosheng very sad. If it weren't for the patient's aunt's distrust delaying the best time for rescue, Wang Gaosheng believes he could have saved Xu Ming. Gu Shiyi and Jiang Yu comfort Wang Gaosheng, but they always miss the mark, repeatedly stepping on his landmines. Wang Gaosheng returns home at night and sees his mother and younger brother waiting downstairs. He brings his family home, and Su Qing is busy preparing a big table of food for them. At the dinner table, Wang Gaosheng hears that his younger brother Wanli has something to say. He signals Su Qing to take Nuannuan to the bedroom to eat, and after they leave, Wanli tells his brother the purpose of his trip: because his fruit shop is short of funds, he wants to borrow some money from Wang Gaosheng.

Wu Dachuan's insistence on keeping the child leaves Qin Wenbin helpless. Qin Wenbin encounters Liu Ziyi, whose waist injury has relapsed, and takes her to a traditional Chinese medicine clinic for treatment. During this time, Qin Wenbin reveals Aunt Jiang's ward information, and Liu Ziyi's visit leads to a misunderstanding. On the other side, Huang Tianming, encouraged by Liu Ziyi, returns to the hospital and decides to undergo surgery on his lucky number 26. Qin Wenbin discovers that Wu Dachuan's wife, Jiang Xue, is visiting patients under a false identity, and learns that she is collecting evidence of her husband's cheating, putting him in a dilemma due to professional ethics. Gu Shiyi is emotionally touched when she receives a mother from a car accident, recalling the trauma of her parents' death. Jiang Yu comforts her and suggests a dinner. Everyone gathers at Jiang Yu's hot pot restaurant and unexpectedly discovers that he comes from a wealthy family with 38 branches.

Jiang Yu takes his colleagues to his hot pot restaurant for dinner, but is interrupted by an emergency call. Gu Shiyi is indifferent to Zhang Yu's poisoning incident when she leaves. Liu Ziyi encounters her high school classmate's younger brother, Ding Hao, and after returning home, she talks to her father about Aunt Jiang for the first time, understanding and supporting her father's pursuit of happiness in his later years, and the father and daughter reconcile. Gu Shiyi helps a car accident patient's daughter visit her mother, and Zhang Yu, after witnessing the rescue scene, has a new understanding of the doctor's profession, and their relationship gradually fades. Qin Wenbin has a conflict with Pan Yue because she asks him to favor Jiang Xue, showing the conflict between a doctor's professional ethics and personal feelings. Wang Gaosheng unexpectedly receives a hot pot restaurant stored value card from Jiang Yu's family, adding warm details to his family life.