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While Martin continues to struggle with his blood phobia, a mermaid washes ashore in Port Wenn to the amazement of everyone in town. Meanwhile, Judith, a well-meaning townsperson (guest star Andrea Martin), creates havoc while on prescribed oxygen, Louisa continues to see Martin's girlfriend Eden for medical guidance and Greg and George's success from the seas urchin boom take its toll on the both of them.

When the Port Wenn pharmacy is robbed, including Louisa’s critical time-sensitive medicine, Martin deduces that the culprit desperately needs his help. Meanwhile, Greg and George clash with a rival food truck owner, Sarah tries to bond with Eden, and Martin is on the receiving end of a special brand of Port Wenn affection.

The citizens of Port Wenn get competitive during their annual floating crate race; Martin tries to give important medical advice when three men have positive pregnancy tests; former record-holder Sarah coaches Peter in the art of crate racing.

As Martin desperately tries to leave Port Wenn to meet Eden in Boston for the weekend, he must first investigate the extremely strange behavior of three patients who have all recently visited a meditation retreat. Also, Mark is affected by the high school's graduation and Sarah's first guest in her rented spare room is none other than ex-paramour Eddie McCroy.

When the wife of a traveling magician duo dies at the Salty Breeze, Martin must help the husband who is unable to grasp that she is gone. Also, Eden finds a letter Martin wrote to Louisa thinking it was for her and Martin gets a new medical monitor who has an instant connection to Louisa.

Martin works to debunk the sudden miraculous cures for the people of Port Wenn when self-proclaimed homeopath Savannah returns to town; Martin becomes acutely aware of Louisa and Parker's new connection.