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In einem türkischen Dampfbad wird der Buchhalter Buddy Overstreet zufällig Ohrenzeuge eines Mordplans von Gangstern, die ihn daraufhin als unliebsamen Zeugen aus dem Weg schaffen wollen. Da ihm die Polizei nicht glaubt, bleibt ihm nur ein Ausweg: Die Flucht!!

Auf seiner Flucht vor der Mafia versteckt Buddy sich auf dem LKW eines Farmers. Dieser bietet ihm Arbeit auf der Farm an. Buddy verliebt sich bald in dessen hübsche Enkelin, doch bei einem Tanzabend wird er aufgespürt..........

Profiboxer Frankie und sein Manager sehen in Buddy den perfekten Sparringspartner für das Training. Doch Buddy schlägt Frankie K.O. und muss dessen Stelle im Kampf einnehmen. Er ahnt nicht, dass die Mafia wieder ihre Finger im Spiel hat..........

Buddy hat richtigen Ärger. Die Schießwütige in die Jahre gekommene Killerin Mrs. Ferguson ist ihm auf den Fersen. Sie will ihren Job so schnell wie möglich zu Ende bringen und legt sich - zum Glück für Buddy - am Ende selbst mit der Mafia an.

Buddy lernt auf der Flucht den Privatdetektiv Klute kennen und erzählt ihm seine Geschichte. Die Mafia kommt dahinter und verhört Klute. Um Buddy zu helfen nimmt er selbst den Auftrag an ihn zu erledigen. Kurz darauf meldet er Buddys Tod. Doch der Schwindel fliegt auf.

Auf seiner nächsten Station wird Buddy gleich von zwei Killerbanden verfolgt. Es gelingt ihm glücklicherweise immer wieder, die beiden Banden gegeneinander auszuspielen.

Buddy trifft auf seiner Flucht einen asiatischen Jungen, der selbst von zuhause ausgerissen ist. Damit Buddy seinen kleinen Freund zu dessen neuen Eltern bringen kann, vereinbart er eine Stunde Waffenstillstand mit Mr. D.

Mr. D., Junior and Wendell are at the boxing matches; Frankie Phillips TKOs his opponent. Later, in Mr. D.'s office, Wendell asks, ""Profitable night, Mr. D.?"" To which Mr. D. replies, ""Extremely so, I had 10 grand on Phillips."" It turns out Phillips was the underdog, but Mr. D. owns both fighters-- he advises Junior, ""It's okay to bet, but never gamble."" (laugh track) The hotline rings; it's an Overstreet sighting, in Louisville, Kentucky. Mr. D. sends Wendell and Harry. But by the time they are getting there, Buddy is already on a road 55 miles south of Louisville, hitchhiking to Mexico; Wendell and Harry drive right by him!* Frankie Phillips and his manager Marty Mason are driving to Memphis, Tennessee, for a fight; Phillips says he will need a sparring partner-- by coincidence, they pick up hitchhiker Buddy. (They have no idea who Buddy is.) Meantime, back in New York, Mr. D. and Junior decide to watch Phillips' next fight in Memphis; Junior tells dad it's 1,122 miles to Memph

Buddy is in a factory, working as a welder. He makes the mistake of telling coworker Stan that Devere Enterprises has put a price on his head. Stan double-crosses Buddy, and phones Mr. D.'s office long-distance. Meanwhile, in New York, healthy Mr. D. and his sickly son Junior are getting their annual physical. But ambitious Mr. W. is double-crossing his boss Mr. D. -- in private, Mr. W. tells the doctor to tell Mr. D. he only has 3 months to live. When Mr. D. and Junior wonder why the doc is taking so long in his private office, Mr. D. quips to Junior, ""He's probably having a little trouble finding your blood in the test tube."" The doctor comes out and asks Junior to leave; and then he tells Mr. D. the bad news: he only has 3 months before he dies. Mr. D. thinks he's talking about sickly Junior. When the doc says it's him, Mr. D. does a double-take: ""before *I* die?!"" Later, Woodrow and Harry are paying Stan $2,500 for his tip. Stan tells Buddy he is has a phone call, from the

Mr. D. has been foiled repeatedly in his attempts to rub out Buddy Overstreet. So Mr. D. sets up an elaborate plan to trap Buddy. But due to an identity mix-up, the tables are turned, and it is Wendell who falls victim to Mr. D's Revenge.

Everytime Wendell goofs up and lets Buddy Overstreet slip through his fingers, Mr. D. says, ""Good-bye, Wendell"" -- and Wendell has to jump out of a speeding car, or jump off the 12th floor balcony of the Devere Enterprises building. But when Wendell seems to disappear for good, the search is on to find Wendell. In an ironic twist of events, it is now Buddy Overstreet who must try to find Wendell, instead of the other way around.

In the steambath, Buddy had overheard the code words ""Chicken Little,"" which indicated the first part of a master scheme Devere Enterprises had. But now, phase 2 of the plan is in effect: ""The Sky is Falling."" Once again, Buddy is in the wrong place at the wrong time-- when he overhears those words, Mr. D. and his boys come gunning for Buddy again.

After Mr. D. had been chasing Buddy all season, he finds himself being chased: by tax auditors. Devere Enterprises may have to shut down their illegal operations and go legit. Wendell and Harry get regular jobs. Since McGregor had turned state's witness against Norton and Joseph, the secret of ""Chicken Little"" is out; so Mr. D. is no longer hunting for Buddy. So now, when he reads a missing persons ad: ""Buddy Overstreet, Please Come Home"" he can finally go home to his family.