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La nueva detective de homicidios de Pittsburgh, Catherine Jensen, está obsesionada desde hace años con la desaparición de su hermano, y con que sus padres haya perdido el interés en encontrarlo. Sin embargo, debe centrarse en su nuevo trabajo cuando se localiza un cuerpo momificado. Se da cuenta de que no es simplemente un accidente o un asesinato aleatorio. Para ayudarla en el caso recluta al psicólogo forense Pr. Thomas Schaeffer quien sugiere que puede tratarse de un asesino en serie. Cuando Catherine es secuestrada por el asesino, el profesor Schaeffer debe ponerse en la piel del asesino para poder resolver el caso y salvarla.

While Catherine waits to be cleared for duty by the D.A.'s office, and Thomas secretly investigates Catherine's past, a brutal murder and a John Doe suicide are discovered.

As the killing escalates, Catherine uses the investigation of the two victims to push Thomas to research her allegations further.

Catherine is forced go to Howard for more information on the case, while Thomas has a real conversation with John about getting inside the minds of murderers. Using Thomas' narrowing profile, Catherine closes in on the killer.

Thomas' decision to stop working on active cases causes Catherine to investigate his past, leading her to an unexpected family history. Catherine takes Thomas to the scene of her childhood trauma where she finally reveals all the details that still haunt her.

Catherine dives into a new case to distract herself from the revelation she heard from Thomas regarding her mother's knowledge. Meanwhile, Thomas ventures too deeply into the mind of a killer.

Catherine takes on a unlikely role when she looks at Thomas' profile and the killer strikes another family.

Thomas becomes obsessed about an ominous letter that puts his career and family in serious jeopardy. Catherine works to overcome a personal loss.

As Catherine comes to terms with the death of her mother, Thomas struggles to keep her under his control. The killer who is abducting people, continues to abduct couples.

Thomas and Bisgaard try to keep Catherine calm after Molbeck is attacked; Catherine and Thomas face their greatest foes.