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On the last night of a senior trip to Aruba, 18-year-old Natalee Holloway disappears. Her mother Beth races to the island and a frantic search begins.

As tensions with locals rise, the main suspect evades custody. The investigation reaches a grim turning point that leads Beth to work with the FBI.

Five years to the day Natalee vanished, a murder occurs halfway across the world. Soon after, Beth seizes the chance to confront her daughter's alleged killer.