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An intense solar flare from the Sun creates a wave of radiation over the Earth. At the same time, Gamma Base is in charge of the highly powerful substance Perium-99. With the base's radio communication equipment rendered useless by the radiation, Dr. Octopus decides to use this opportunity to steal the Perium-99.

The Sonar Crystallizer, a highly powerful device capable of reducing anything to dust, is due to be tested at Gamma Base, and a villain known as the Spymaster sets his sights on it. Meanwhile, Rio tells Rick about an ancient curse that befell a prince of the Yucatan in South America.

In the desert of New Mexico, a mysterious U.F.O. is detected close to Gamma Base, an army facility where a new weapon known as the Gamma Bomb is due to be tested. The inventor of the bomb is Dr. Bruce Banner, assisted by his fiance Betty Ross and the edgy Dr. Carlson, who is very eager to get a hold of Banner's Gamma formula. The U.F.O. is shot down by fighter jets, but not before an escape pod is secretly jettisoned.

In Paris, Bruce and Betty are meeting with the Academy of Science, with Betty carrying one of the gold keys that opens an underground gold vault. Quasimodo, the evil great-great-great- great-great-grandson of the original hunchback of Notre Dame, spies on Betty in order to steal the gold and plans on using one of the assembled scientists to turn him into a normal human.

Cyclops, the largest and most powerful computer on Earth, is due to be granted full control over the U.S. entire military defenses.

General Ross makes the capture of the Hulk Gamma Base's primary objective. Meanwhile, the villainous Puppet Master sets up operation in Mesa City, and begins controlling everyone in the town, with the Hulk also in his sights.

In New York, Dr. Brandon Jones, Rick's uncle, has successfully developed the Time Project, a time machine. Rick tells Bruce, who hopes to use the machine to travel through time and prevent himself from ever becoming the Hulk by stopping Rick from entering the Gamma Bomb test site.

At Gamma Base, Dr. Proto is attempting to create a new form of life, and proceeds to draw power from Bruce Banner's new Gammatron experiments against Banner's request.

Bruce is experimenting with a gamma ray emitter on a lab rabbit, when it suddenly short circuits and after being bombarded with the ray, reduces the rabbit and then Banner in size to only one inch tall.

Bruce finds himself in a windswept landscape, running away from none other than the Incredible Hulk!

In Los Angeles, criminal lawyer Jennifer Walters, who is investigating the criminal organization Hydra, has just had a medical check-up by Dr. Steve Perry, when the Medical Center comes under attack by Hydra soldiers. Jennifer decides to pursue them.

As Bruce supervises a space shuttle gantry on Gamma Base, the whole structure collapses and injures Jeff Kessler, the chief project engineer. Betty's quickly arrives with her nephew Jonah, who claims that he can see into the future.

At Gamma Base, Bruce and Betty are testing the new Transmat, a device that can transport an object from one place to another. Bruce volunteers himself as a human test subject, but during the process, the Transmat beam changes him into the Hulk, who is transported to Betty's end of the beam. The Transmat is destroyed by the Hulk, who then escapes from the base.