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The early boxing career of Cassius Clay includes a gold medal win at the 1960 Olympics in Rome; after converting to Islam, Clay changes his name to Muhammad Ali; Ali is stripped of his heavyweight title for refusing induction into the military.

Ali becomes the first three-time heavyweight champion of the world, but the toll of so many historic ring encounters starts to show; "The Greatest" travels the globe as a goodwill ambassador, philanthropist and activist.