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Bad Mouse and his rodent followers steal the city mint.

Fishface uses his trained dolphins to capture millionaires on their yachts and has his henchmen disguise themselves as them.

A cat burglar named Catman uses his trained his pet lion and black panther to steal the worlds largest diamond.

A scientist named Dr. Lash thaws out a Viking warrior named Kragg the Conqueror and his hound. He then plans to use them to abduct the mayor, the police chief, and Mighty Man.

Miro The Mentalist uses a mindreading machine that enables him to steal valuable information from the brains of his victims.

Fed up with guard dogs spoiling his crimes, a small-time criminal becomes the Dogcatcher, luring and capturing dogs with a sonic whistle so he can eliminate every dog on Earth, including Yukk.

Future Man, a fully evolved human with futuristic powers, plans to turn the whole of mankind into cavemen.

Camera Man uses his 3-D camera to travel through any television in the city and commit robberies.

Krime Klown uses his Krime Kazoo to turn the citizens into his circus henchmen.

Copycat and his henchman Ivan plot to steal the fortune and money belt of oil tychoon Bucks Galore.

Former TV villain Nefario creates a super suit which enables him to stay one step ahead of Mighty Man and Yukk while he is committing a series of crimes.

Marble Man uses a device to bring statues to life in a plot to drive out the citizens and claim the city for themselves.

Evila the Witch enchants the city's gems into following her back to her house.

Dr. Locust attempts to steal three ancient Chinese junks that once combined creates a robotic warrior.

Stanley Johnson is set to inherit a fortune if he spends the night in a haunted house. The only problem is the Creep and his henchman Clyde plan to kidnap Stanley so that the Creep inherits the money himself.

Doctor Icicle and his sidekick Frosty are kidnapping renowned scientists in order to build a super freezing machine that will freeze the sun.

An evil professor named Sanfon Vulch creates Glop, a monster that can eat its way though anything. Glop is sent to Brandon Brewster's house to eat through his safe and steal a set of valuable blueprints.