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The friends spread their wings and fly towards independence. Cristina and Angel announce the date of their wedding and begin wedding planning. Rachel, determined to live on her own, asks Megan to be her roommate. John takes the necessary steps towards getting his driver's license. Sean's determination to get a tattoo drives a wedge between him and his father.

While picking out a wedding dress, powerful emotions are brought up for Cristina and Bea. Elena desires to take her relationship with William to the next level. On a journey to health and wellness, Megan and John visit the Chopra Center, where both amusement and self-discovery ensue.

Cristina and Angel meet with their wedding planner and learn the art of compromise. Rachel celebrates her birthday in Vegas surrounded by friends and family. Megan searches for an additional source of income to further her goal of financial independence and grow her “Megpire.”

Megan and Rachel make the big move into their new place, which presents its fair share of trials and tribulations. Hiromi and Stephen seek out guidance on whether or not they can move back to Japan and leave Elena in the US. Angel and Cristina hit a bump in the road over a misunderstanding about Cristina wanting to date other people. The group boogies down at Drag Queen Disco Bingo, where they meet Elena's new beau.

Megan and Rachel adjust to living independently, while Kris and Laurie struggle to let go; the Kellers start to teach Rocco independence; Sean finds comfort in his relationship with Caley.

With the help of some cute firemen and a self-defense class, Rachel and Megan learn to stay safe while living alone; they celebrate their independence with a no-drama party; John and Steven get behind the wheel at last.

As Cristina and Angel's wedding date quickly approaches, Cristina reaffirms her commitment to Angel by surprising him with a gift, while Angel takes lessons on being a good husband and prepares to move in with Cristina.