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Dr. Sam Stewart runs a remote medical clinic on Hope Island in the Great Barrier Reef. She's a GP, but in her spare time she and her colleague, Gus, chase the venomous creatures that inhabit the area.

Sam and Gus go on a monitor lizard hunt while the new doctor, Rick, has trouble adjusting to working in a remote clinic. Meanwhile, a new bride on her honeymoon steps on a deadly stonefish.

To pay for a much needed outboard motor, Sam gives a lecture to Andrew's medical students at the Mainland University. Whilst there, she discovers her rival Malcolm has a newly renovated hi-tech lab.

On Freya's day off, Sam & Gus take her on a venomous spider hunt. When Gus falls into a stinging bush & Sonny loses consciousness out on the reef, Freya experiences a real test in emergency medicine.

It's a busy monthly clinic day on Hope Island and Rick is keen to see some new patients. Sam and Livvy try to get him to improve his bedside manner and listen to their complaints.

Andrew tells Sam that her clinic may be in line for an upgrade but when she heads to the university to discuss the details, she discovers he means to give her research to an independent research foundation.

Toby runs into trouble with sharks while diving alone, in secret. Meanwhile, romance is in the air as Gus asks Livvy out and Rick and Freya discover their mutual attraction.

Sam is getting some deadly cone shells as Andrew calls with the news that the Foundation has decided to fund her venom cream.

Sam and Jack looking forward to a couple of wildlife film-makers, come to the island for a bit of a holiday and to film for their leatest television series.

Sam organises a ceremony to scatter her father’s ashes. Andrew is bringing his girlfriend and her daughter and Jack predicts the event will end in disaster.

A wild storm causes damage to the Clinic’s satellite dish. Freya is intrigued to find out something something about Rick’s past.

When Toby finally finds a relic from a shipwreck that will triple in value all the artifacts he has so far collected, an excited Erica flies out to see the piece for herself.

The arrival of some dangerous Irukanji jellyfish closes down Sonny’s Beach. Sam finds a huge aggregation of them and uses some for her research.