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The opening episode is the first documentary film to examine the case of Joanna Dennehy, one of only a handful of known British female serial killers. Growing up, Dennehy was a normal happy child. She excelled at school and sports and her parents dreamed that she would end up at university studying law. That the thirty something mother-of-two became responsible for the horrific murder of three men in the space of ten days shocked those around her.

David is in America to analyse how the unusual behaviour displayed by Dennis Rader as a child gave an early indication that he would grow up and become a psychopath.