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For untold generations, America's national mammal sustained the lives of Native people, whose cultures were intertwined with the animal. Newcomers to the continent bring a different view of the natural world, and the buffalo are driven to the brink of extinction.

By the late 1880s, the buffalo that once numbered in the tens of millions is teetering on the brink of extinction. But a diverse and unlikely collection of Americans start a movement that rescues the national mammal from disappearing forever.