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Doctors from various fields and with various personalities come together and formed the "Night Doctor", specialized in night-time emergencies. This drama will show the challenges they face every night and how they slowly create a unique bond.

Mitsuki witnesses the scene of an affair. Her colleagues see through her unusual behavior and is told not to let personal feelings interfere in the workplace…

Inspired by his hometown, Ying Ting aims to be an emergency physician, but his mother forces him to study in the UK. At this time, there was something wrong with the patient in front of Sakurai ...

Shiori Garden became entangled with her boyfriend and became her boss, and Takaoka finally lost control of her emotions. One day, Shiori realized that he was suspected of having a mental illness.

Naruse is accused of medical malpractice and will resign if he loses! ?? In order to demonstrate her skills, Mr. Asakura went to the clinic as a part-time job and was tired and had an accident in the disaster area! !!

Mizuki was injured on the scene, and Fukasawa blamed himself and tried to cheer him up. Can Mizuki, who complains about the difficulty of shortening working hours and accumulating experience, understand the true meaning of labor reform?

How can a night doctor escape the label of a second-class doctor? What goals do they have?

There is a chance to return to neurosurgery, but Naruse is undecided. On the other hand, can Fukasawa catch Mizuki's heart on a date?

Fukasawa fought a big battle with Sakuraba about Shinmei's desire to donate organs. Will Mizuki discover Sakurai's secret?

Mizuki Asakura's philosophy of "Asahi Kaijin Hospital" collapses. That day, Mizuki was asked by Hiroshi Hoshizaki for a hotline to deal with a man suspected of having a thoracic aortic dissection. Hoshizaki complains that the man has been active for more than two hours, but Toru Hongo tells Mizuki to decline. Mizuki responded by accepting a woman in her fall from a height. Makoto Fukasawa and Mitsuho Takaoka don't think they can go to the hospital, but Hongo asks Mizuki to drive in 15 minutes. When Mizuki asked the Messiah, he replied that it was possible, and Hongo allowed him to accept it. However, after exceeding the transportation time, the woman arrived at the hospital. Mizuki, Akito Naruse and others worked hard, but they couldn't save the lives of women.

Toru Hongo's Mizuki Asakura, Akito Naruse, Makoto Fukasawa, Mitsuho Takaoka, Shun Sakuraba and others have blamed the dissolution of the Night Doctor team. It was a problem that Chairman Reiko had already notified Hongo of the decision of the Kashiwasakurakai Board of Directors. The sudden news shocked Mizuki and her Night Doctor. On the night of the notice of dissolution, three accidents occurred at the same time, and Night Doctor went to each site.