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박철은 전쟁을 막기 위해 김일성의 심장 수술을 하러 아들 박훈과 북한으로 가게 된다. 북한은 아들 박훈의 목숨을 담보로 박철에게 수술을 집도하라고 한다. 수술은 성공했지만, 남한으로부터 버림받은 두 부자는 북한에서 살게 된다. 그 후 박훈은 재희를 만나 평범한 삶을 꿈꾸고 있었다.

Park Hoon is sent to Hungary to perform a difficult surgery. While there, he attempts to escape the North's clutches along with his childhood crush, Song Jae Hee.

When a horrendous traffic accident creates chaos at a local hospital, Park Hoon winds up preforming an unlicensed surgery to save a dying father.

After impressing the hospital staff, Park Hoon is hired to head up a new surgery team, but his North Korean past creates tensions with the existing staff.

When Park Hoon is fired after performing a controversial surgery, he finds a chance to redeem himself using his surgical skill.

Park Hoon is emotionally tormented as a doctor who looks exactly like his lost love Song Jae Hee continues to insist that she is not.

As the competition to perform heart surgery on the Korean Prime Minster heats up, the pressure is on Park Hoon to once again show off his surgical skills.

Back room power struggles at the hospital threaten the legitimacy of the competition while evidence mounts that the Han Jae Joon may not be all that she seems.

The surgery competition finally begins only to end with a shocking twist. Meanwhile, pressure is mounting on Jae Hee to complete her mission

Han Jae Joon and Park Hoon's long awaited reconnection is cut short when they are both kidnaped and taken back to the north.

Han Jae Joon uses Park Hoon's illegal action of looking at private medical records as leverage to reinstate their competition.

The competition takes a dark turn as Park Hoon's loyalty to the hospital is put to the test and not just his surgery skills.

When the prime minister announces he will have his heart surgery at a different hospital and a looming malpractice suit begins to take form, the staff at Myung Woo Hospital fear for their jobs.

Allegiances are tested when Jae Hee finally reveals her true intentions to Park Hoon.

Park Hoon is reprimanded after performing a very risky surgical procedure in a last ditch effort to save a dying patient.

The competition between surgeons reaches a boiling point as Han Jae-joon is desperate to prove himself.

In the final round of the competition Park Hoon is forced to confront what it truly means to be a doctor.

The prime minister finally reveals who will perform the heart surgery.

Park Hoon is once again forced to use the risky SAVER procedure to save the president.

In the thrilling conclusion to Doctor Stranger Park Hoon and Jae Hee make the ultimate sacrifice to be together.