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Richard Sackler begins to launch a powerful new painkiller, a rural doctor is introduced to the drug, a coal miner plans her future, a DEA Agent learns of blackmarket pills, and federal prosecutors decide to open a case into OxyContin.

OxyContin is on the market but faces a potential threat, Purdue's vast influence reaches the town of Finch Creek, Bridget steps outside her DEA authority, and the criminal investigation of OxyContin begins.

Doctor Finnix begins to taper Betsy off OxyContin, Bridget sees the toll the drug is taking on communities, Rick and Randy investigate the world of "pain societies", and with sales climbing, Richard Sackler makes bigger plans for his new drug.

Sky-high OxyContin sales are threatened by reports of abuse, prosecutors investigate a claim central to OxyContin marketing, and Finnix begins to question the safety of the drug.

With OxyContin abuse spreading across the country, Bridget brings the fight to Purdue while Rick and Randy seek to find a whistleblower within Purdue to tie their case together.

Richard Sackler faces a catastrophic challenge to Purdue's bottom line, Bridget takes her fight to the FDA, Finnix reassesses his life as Betsy struggles to kick her addiction, and Rick and Randy find a bombshell piece of evidence.

Richard Sackler and Purdue work the system to prevent their drug from being reigned in, Bridget has a breakthrough in her mission, Betsy has hit rock-bottom while Finnix explores new avenues, and Rick and Randy ready their criminal case.

Rick and Randy's criminal investigation now threatens Richard Sackler's empire, activists take action against Purdue, and Finnix tries to heal his beloved community that's been ravaged by addiction.