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Locals and comedians guide Sue through Colombia and Mexico as she tests a bulletproof vest, rows through rapids and braves a fireworks festival.

After experiencing lucha libre and meeting a bone cleaner in Mexico, Sue soars over the beaches of Brazil and performs a rap song at a favela funk ball.

Sue visits a love motel in Sao Paulo before heading to higher altitudes in La Paz, Bolivia, where strong emotions surface after a mind-altering trip.