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Manu, a rookie nurse, gets an internship at Unit 53, led by Dr. Irene. They respond to an emergency in a community, where a van has crashed into a small bar.

A congressman suffers a heart attack while having sex with a prostitute. Dr. Pedro, Manu, and Vandam are called to a hotel to treat him, but when they arrive, they are met with an unfortunate surprise.

Dr. Glória is forced to confront the ghosts of her past when she has to find a hospital bed for a hit-and-run victim at a public hospital where she used to work.

On her birthday, Vanessa reflects on her journey while working with Dr. Pedro and Manu to treat a family electrocuted in a car accident.

While treating a woman who was beaten by her husband, a jealous military officer, Átila is forced to confront past traumas from his time as an army nurse on a mission in the jungle.

Dr. Pedro, a bipolar surgeon, is reminded of his childhood with his sick mother when he responds to a call involving a boy who finds his mother unconscious in an apartment.

Duda tells Átila about her past and her adult-content career, only to find herself treating a prostitute who has been beaten—an old colleague of hers.

After escaping from prison, Vandam's father, Marcelo, carries out a wild plan: he and his criminal accomplices invade Unit 53 and take the entire team hostage.

While responding to a case involving a deranged man who stabs a groom and takes the bride hostage, Manu is reminded of her brother, who was kidnapped, and the nurse who cared for him.

On a rainy night, a landslide buries a family's car. Irene must bring the Unit 53 team together to rescue everyone trapped in the accident.