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The heart transplant operation of a famous politician is held at Taesan University Hospital. Park Tae Soo works on that operation together by Choi Seok Han’s request, but he leaves the hospital with the donor’s heart. Why did he leave with the heart? What happened to make this happen? Stay tuned to find out.

Tae Soo’s mother gets in a critical state, and Tae Soo becomes desperate to find a doctor who is willing to take her in. Tae Soo and Woo Jin frantically search for a hospital available, but they keep having difficulties. However, they finally reach Choi Seok Han by calling his number.

Seok Han decides to do the surgery for Tae Soo’s mom. Later, Tae Soo joins Taesan University Hospital as a fellow. However, he seems to be always cleaning up after Dong Joon’s mess. As such days go by, Hee Dong suddenly orders Tae Soo to send a dying patient to another hospital.

Tae Soo decides to do surgery for the patient he was ordered to send away. He manages to succeed with the help from Seok Han. Meanwhile, an emergency occurs during Soo Yeon’s way back to Korea. Soo Yeon has no choice but to take the patient to the nearest hospital, but they don’t have the equipment and supplies needed.

Finding himself in a critical situation with no other viable option, Doctor Park Tae Soo convinces Doctor Yoon Soo Yeon to use super glue and a piece of a latex glove to patch a bleeding heart. Miraculously, the makeshift patch stops the bleeding, and the patient is rushed to Taesan University Hospital. Meanwhile, as Tae Soo prepares to go in for surgery, his mother calls to hear his voice..

Tae Soo’s mother goes into cardiac arrest. Luckily, Doctor Yoon Soo Yeon manages to get her on the ECMO machine and saves her life. With his mother in stable condition, Tae Soo meets with the family members of the patient who suffered the cardiac tamponade and decides to disclose that super glue was used to save his life. Right then, he sees who the uncle is and reconsiders telling the fact.

Knowing her very existence could have been the reason for Professor Choi not being able to save his daughter's life, Soo Yeon visits Yoo Bin’s memorial to show her respect. Tae Soo watches Professor Choi tormented by the memory of losing his daughter and walks away in sympathy. Despite his brother being alive, Hwang Jin Chul shows up to the hospital and threatens Tae Soo for using super glue.

Taesan University Hospital director, Yoon Hyun Il, fires Tae Soo after he hears of his super glue procedure. However, his brother, Yoon Hyun Mook, the chief executive, hears about Hyun Il diverting funds from the Africa project and plans to have Hyun Il resign. Meanwhile, Soo Yeon sides with Tae Soo and tries to find a way to save his position at the hospital.

Blackmailed, Professor Choi Seok Han faces a predicament that could lead him to find out the truth behind his daughter’s death. The thought of never finding out what happened torments him and pushes him to the surgery room. Meanwhile, Tae Soo stands on guard and opposes the idea.

Tae Soo’s mother finally awakes from surgery but still urgently needs a heart transplant. Soo Yeon has difficulty breathing and plans to have surgery done by Professor Choi Seok Han. Meanwhile, Professor Choi Seok Han suffers from knowing the truth about his daughter's death and plans to get his revenge.

Even with Hyun Il's confession and a plea for forgiveness, Hyun Mok stands firm on his decision to see him leave Taesan University Hospital. After meeting with Hyun Il, Hyun Mok and Soo Yeon get into an accident and are both seriously injured. As he lay dying, Hyun Mok begs Professor Choi to save Soo Yeon's life once again.

The faculty attends Hyun Mok's funeral and starts to gossip. Everyone knows with Hyun Mok dead and Soo Yeon grasping onto her life, Hyun Il will become the hospital's chief director. Moreover, what Professor Choi Seok Han yelled as he tried to save Hyun Mok, starts to echo. Later, a braindead patient arrives at the hospital.

Professor Choi Seok Han asks Tae Soo's mother a very tough question that puts her life on the line. Knowing that her decision will save another doctor's life, she consents to give the heart that was for her to Soo Yeon, who is in critical condition. Tae Soo is heartbroken when he finds out and blames Professor Choi for making the wrong decision.

After giving up the heart, Tae Soo's mother condition worsens. Taesan University Hospital inaugurates Yoon Hyun Il as the new director, and Soo Yeon regains her conscience. However, when she wakes up, the sight of her uncle frightens her. Meanwhile, Professor Seok Han prepares a press conference to promote the hospital.

Tae Soo holds his mother's funeral. The operating team comes to say goodbye and to give Tae Soo support, except for Professor Choi. The newly appointed hospital director, Yoon Hyun Il, has lunch with his staff and later, calls Professor Choi for answers. Meanwhile, Ji Na and Dong Joon argue over who should be taking care of Soo Yeon.

A year passes. Soo Yeon fully recovers and becomes an assistant professor at Taesan University Hospital. Professor Choi proposes to perform a new procedure to save fetuses with congenital heart disease, but Soo Yeon opposes. However, Director Yoon agrees and approves the operation and for Soo Yeon to assist.

Soo Yeon finds out the triple-A patient went to Haemin Hospital instead of coming to Taesan University Hospital. She takes the requested blood to Haemin Hospital knowing that Park Tae Soo would be operating. Meanwhile, Professor Choi and Taesan University Hospital prepare for a live broadcast of the nation's first angioplasty procedure on a fetus.

The live procedure is about to near, but Soo Yeon opposes the surgery and tries to convince Professor Choi to reconsider the risk. Tae Soo continues to accept emergency patients Taesan University Hospital declines and later discreetly goes to see Professor Choi's career-changing surgery. Meanwhile, someone sends Tae Soo a mysterious package.

After finding out that Professor Choi had purposely put him to sleep, Tae Soo goes to see Professor Choi unannounced. However, instead of asking for the truth, Tae Soo asks Professor Choi if he can return to Taesan University Hospital. Later, while Soo Yeon presents a patient's case to the directors, Professor Choi announces that Tae Soo will be the one to operate.

Tae Soo returns to Taesan University Hospital under the consent received by Professor Choi and is scheduled to perform surgery on a very urgent patient the very next day. However, with Chief Koo picked as one of the doctors for the show "Best Doctors," Tae Soo's surgery gets postponed. Meanwhile, Soo Yeon recollects the incident that killed her father and suspects it to be someone's doing.

Tae Soo finishes up his first surgery with the help of Soo Yeon who now starts to understand Tae Soo's drive to be a surgeon. Director Yoon proposes a vision to Professor Choi and asks him to perform surgery on a very attention-grabbing presidential candidate. Meanwhile, the production director for SBC asks Tae Soo for an interview regarding the operation.

Chief Koo walks in Tae Soo's interview and swivels the spotlight back onto himself. Still suspicious of her father's death, Soo Yeon tries to find out more about the slush funds generated from the Africa Hospital project her uncle, Director Yoon, had operated. She even looks for the truck driver responsible for the accident but finds out he had left the country. Meanwhile, Hwang Hyun Gi, the patient saved by Tae Soo and Soo Yeon, starts to bleed profusely while being transferred.

After visiting her father at the temple with her uncle for his one-year death anniversary, Seo Yeon confronts her uncle about the slush funds and tells him he should leave Taesan. Later, Seo Yeon and Professor Choi debate over performing surgery on a five-month-old baby with Edwards Syndrome. Meanwhile, Professor Choi agrees to perform heart surgery on the presidential candidate, Han Min Sik, in return for a pediatric cardiology center.

Despite Professor Choi's dissenting words, Soo Yeon performs the surgery on the baby with the help of Tae Soo. Director Yoon and Professor Choi approach Han Min Sik and try to coax him into getting a heart transplant at Taesan University Hospital. They promise he will be able to run through the primaries with a donor heart waiting at in the end. Meanwhile, each member of the OR does an interview.

When Han Min Sik's aide dies on the operating table, Director Yoon smiles. However, Soo Yeon, who is watching the surgery with him, notices his smile. Meanwhile, Professor Lee and Chief Koo ignorantly think that their chances for the chiefship is between themselves and start to giggle at Professor Choi's supposed downfall.

Even with death on the operating table, Han Min Sik arrives at Taesan University Hospital to undergo a VAD implant procedure at the hands of Professor Choi. The whole surgical ward is closed off to facilitate the VIP, putting Tae Soo and Woo Jin scrambling to find an operating room to save a Type-A dissection patient. Meanwhile, the surgical team awaits Han Min Sik's arrival in the operating room.

The operating team leaves Professor Choi's surgery and joins Tae Soo to save an emergency patient. For his direct disobedience, Director Yoon orders to fire Tae Soo, but Professor Choi changes his mind. Meanwhile, Soo Yeon finds out that her father had fabricated the blood test results of Professor Choi's daughter, Yoo Bin.

Director Yoon finds out that there are too many patients staying longer than needed and orders Chief Koo of the Cardiothoracic Department to weed out the unneeded patients. Acting on her suspicion, Soo Yeon meets with the daughter of Han Min Sik's aide, who died on the operating table, and digs for answers. Meanwhile, Han Min Sik confirms his candidacy for the presidential election, and Professor Choi asks Director Yoon for something more than just his word.

The atmosphere in the hospital is tense, and everyone is feeling Director Yoon's wrath as a patient dies due to his bias for the wealthy. Director Yoon tells Professor Choi that Taesan will be setting up a cardiothoracic hospital in Russia and warns him that there mustn't be any complications with Han Min Sik's heart transplant. Meanwhile, Tae Soo and Soo Yeon worry that Director Yoon is up to no good.

Director Yoon notices a newly listed child for a heart transplant with both her blood and tissue identical to Han Min Sik's. Later, a code blue occurs and the child, Yoon Seo, goes into cardiac arrest. If it weren't for Soo Yeon and Tae Soo, Director Yoon would have gotten his way and had her die. Luckily, Yoon Seo makes it onto the ECMO and jumps up in priority for a heart, putting Director Yoon in a predicament.

Tae Soo devises a plan and saves Yoon Seo, the girl who desperately needs a new heart. With the help of the surgical team and by duping Director Yoon, Soo Yeon secretly operates on Yoon Seo. Meanwhile, with all eyes on Taesan University Hospital, Director Yoon orders Professor Choi to announce to the press that Han Min Sik's heart transplant was a success.

Yoon Seo recovers fully with her new heart, but with no heart to give Han Min Sik, the situation gets dire for Director Yoon. Stealing one is his only option. Later, with a change of heart, Professor Choi turns the table and puts Director Yoon in the light with unequivocal evidence.