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Jasmine Harman presents a follow-up to last year's My Hoarder Mum and Me, in which she rallied her relatives to tackle her mother Vasoulla's compulsive habit. Despite her efforts, only a few rooms in the family home were tidied, leaving the presenter with little choice but to seek further advice. She meets a man whose garden is so heavily cluttered his council has threatened him with prosecution, and meets experts who help her understand what makes her mother's habit such a debilitating psychological disorder.

Jasmine attempts to help Jeff in Plymouth who lives in a house full to the brim with posessions. He is determined to confront his hoarding and Jasmine helps him move a whole floor's worth of his hoard to a local warehouse so he can sort through it. She also attempts to help Jean in East London who's hoard is so bad she has not been able to live in her flat for years.

Jasmine attempts to help Wendy in south London who is resistant to get rid of the items from her small one-bedroom house following a lifetime of hoarding. She also tries to help Laurence in Northamptonshire who is unable to get rid of even a bag of rubbish.