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Alarm in Düsseldorf: the body of a nurse has been found on the banks of the Rhine, and evidence at the crime scene recalls a series of murders that had terrified the area four years previously. Three women had been killed in exactly the same manner. The obvious connections to the old cases prompt the head inspector to appoint Helen Dorn as chief investigator. In order to solve the nurse's murder, the old cases must be reviewed, whereby Helen and her partner Georgi come upon suspects from among their own police colleagues.

A missing child is at the center of Inspector Helen Dorn's investigations. Mia, the four-year-old daughter of the wealthy businessman Hans Thomsen, has disappeared under mysterious circumstances. The family members are under shock; a kidnapping seems likely. While Mia's mother Inga tries to keep the family together and prevent an escalation, her husband wants to find his daughter on his own. But why does he head so assuredly for Rotterdam? After a difficult start at police HQ with her new partner Gregor Georgi, Helen Dorn begins to discover some very surprising things about Gregor. He, meanwhile, sets out to understand Helen better by uncovering her past…

年輕女子Karla Petersen在家鄉參加慶祝活動之後，在回家的路上被殺。Helen Dorn接手此案，這時她的父親仍處於昏迷狀態。 她在村子裡遇到了當地警官Tom Petersen，他正是Karla的哥哥。儘管Dorn警告他不要捲入此案，Tom仍然堅持不懈地尋找殺害妹妹的兇手，朋友和熟人都成了嫌疑犯。

警方在監視非法武器販運案時，情況擦槍走火，三名波蘭男子死亡，其中兩名是警察。Mattheisen與Helen Dorn分享他的陰謀論：他相信武器是要運給一個激進右翼地下組織，一名國家刑事偵緝處的員工就在組織內擔任臥底。但Mattheisen還來不及告訴Helen Dorn組織的幕後黑手是誰，就死於Helen持有的軍用武器。Helen出現在犯罪現場，手裡拿著槍，但她不記得發生了什麼事。

14年前的男孩失蹤案一直懸在Helen Dorn心上，當時她不得釋放嫌犯Ron Faber，而失蹤的男孩再也沒有出現。Helen無意中透過內部刑警組織的報告，得知Faber在漢堡出事被抓，而且救難人員在他的貨車後面發現了一名中國男孩的屍體，她立即趕往漢堡。

Helen Dorn與法醫鑑識專家同僚Weyer在漢堡參加DOM音樂節，一名年輕護理人員在附近的停車場遭到襲擊並受重傷。兇嫌的手法如此兇殘，震驚的Helen決心找出兇手。第二天，一名漢堡上流社會青年被發現死亡。在調查過程中，Helen和同僚發現了一個將兩起案件連結在一起的黑暗秘密。

Helen Dorn與同僚出勤，同僚卻在她面前開槍自殺，她面對自己的愧疚感以及來自同僚的無聲指控，壓力主要來自督察長Tayfun Murat。同時，她也必須偵破年輕醫科學生的謀殺案。她循線調查來到漢堡一家醫院的腫瘤科，很快就發現受害者一直過著雙重生活。