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Piers Morgan interviews serial killer Mark Riebe. Mark is one of Florida's most ruthless murderers and is believed to have killed more than 13 women in a period from the late 1980's to the late 90's. He was convicted in 1998 of the murder of Donna Callahan on August 6, 1989, and sentenced to 25 years in prison. Piers gets straight to the point to find out what has driven these people to commit such heinous crimes.

Missouri's most notorious serial killer terrorised the streets of Kansas City for over two decades. In this chilling film, Piers Morgan comes face to face with Lorenzo Gilyard, a seemingly ordinary man who killed 13 times before discarding his victims on the streets. Although he is serving six life sentences, Gilyard protests his innocence despite overwhelming DNA evidence against him. Piers Morgan sets out to discover what drove this family man to kill and kill again in a remarkable interview.

Henriquez, convicted nearly 30 years ago for murdering two girls aged 10 and 14, and a 21-year-old woman in the Bronx, has never spoken publicly about his crimes. Now Piers aims to get beneath his lies and deceit to uncover the truth. Alex Henriquez is serving 75 years but continues to maintain his innocence.

Piers travels to Titusville, Florida to speak with Bernard Eugene Giles, who is serving 5 life sentences for the murder of five young women in 1973.