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Castile's new King sets foot on his kingdom for the first time and he is not welcomed. He declared himself king when the titular Queen, his mother Joanna The Mad, still lives. And he intends to rule without speaking a word of Castilian.

The King knows his Flemish advisers only look for their personal interests. Feeling lonely, he finds solace in Germaine's arms.

Maximilian's death leaves the Empire throne vacant. Francis I and Henry VIII want it, but Margaret of Austria will be Charles' best ally in the race.

Charles is the new emperor, but his fight with Francis I is not over. Meanwhile Hernan Cortez and Moctezuma meet.

While Charles is away in Europe, Commoners rise in arms in Castile.

Spain and France meet in the battlefield, resulting in an unexpected prisoner of war.

Europe unites against the emperor. Meanwhile, Isabella is determined to prove herself more than a mere queen consort.

Charles is finally crowned Emperor by the Pope, but joy is quickly followed by tragedies.

It's been years since Isabella's death. While Charles is away from Spain, going from battle to battle, Philip is already a grown man.

Both Charles and Francis are getting to the end of their lives.

Tired of ruling, Charles arranges the distribution of his many kingdoms among his heirs.

Charles V lives his last days in a monastery, sad and tired, accompanied by Francis Borgia. But life will still provide him with one last joy.