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As Dr. Jenna James looks to move past her hospice scandal, she finds her job threatened by a handsome new doctor and takes immediate action. DiDi is inspired to fight for her union rights, while cutbacks force Patsy to return to floor duty. Dawn questions her marriage and, later, gets some distressing news.

The staff faces an infectious disease crisis. DiDi's family drama spills into work--in the person of her sister-in-law, Yvette. Dr. James reaches out to a pharmaceutical company and finds herself affected by a patient with a complicated past. A worn-out Dawn is revived by Patsy's unpredictable advances.

While preparing for an upcoming conference, Dr. James is caught off guard by workplace politics. A felon with cancer - and a history of daring escapes - arrives at the ward. When his mother pays a visit, Patsy asks Dawn to pose as someone she's not. DiDi's mother-in-law comes to Billy Barnes for treatment, sparking a family feud.

On the day of her "Sympoosium," Dr. James is plagued by unexpected complications. Patsy embraces his truth, and DiDi finds herself caught between her work and family. Dawn and Dr. James see uncanny visions of themselves in two British visitors, Dr. Pippa Moore and Sister Den Flixter.

With the ward's fate up in the air, DiDi hunts for ways to save it, while dealing with pressure from Dawn to be her health advocate. Troublemaking Varla returns, and butts heads with her equally opinionated long-lost daughter. Caught in a mountain of lies, Jenna comes clean to her husband, Richard. After a memorial service full of drama, the staff gets a rude awakening.

In the series finale, DiDi walks a picket line in a last-ditch effort to save the Billy Barnes from closing. Meanwhile, Dr. James regrets an offer made in haste; and a student nurse makes a revelation in a secret-sharing session that gets Patsy's attention.