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Jin examines Saki’s ill mother after learning that she may have beriberi disease due to malnutrition. Ryoma arrives from Kyoto seeking Jin’s help.

Jin considers the risks of interfering with history by treating an imperial princess with suspected beriberi. An old acquaintance appears before him.

Locked away in prison for a crime he didn’t commit, Jin endures harsh conditions and torture. Ryoma and Kyotaro fight to prove his innocence.

As the Jinyudo doctors continue trying to create penicillin in powder form, Taki asks Jin for help in treating a noblewoman from an important family.

Jin does all he can to help a renowned kabuki actor suffering from severe lead poisoning and limb paralysis to perform on stage one last time.

While visiting Nagasaki to teach other doctors about penicillin, Jin catches up with Ryoma but senses that something about him has changed.

After receiving a wedding invitation from Nokaze, Saki and Jin go to Yokohama for the occasion. But during the visit, Nokaze wants Jin to examine her.

As Ryoma fully devotes himself to achieving a return to imperial rule, Jin battles to protect the lives of both a struggling Nokaze and her child.

As Jin rushes to Kyoto with Saki and Saburi to prevent Ryoma’s assassination, Kyotaro heads for the same destination with a very different mission.

Jin, Saki and Saburi perform a major surgery to try and save Ryoma’s life. The Jinyudo doctors face charges of teaching how to create fake penicillin.

Sensing he has little time left, Jin resolves to pass on his entire medical knowledge to the Jinyudo doctors. Kyotaro makes a difficult decision.